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Core Concepts for Grief-Sensitive Care

How Grief Affects the Brain

“Grief takes up a lot of room that people can’t see.”

Shari O’Loughlin / CEO of The Compassionate Friends; Bereaved Parent

Grief can affect cognitive functioning in a range of ways. 

Changes in memory, concentration, and decision-making can occur during grief, sometimes described as a sense of “brain fog.” Because these cognitive responses are not always expected, individuals may worry that something is wrong or that they are not coping “well enough,” which can contribute to confusion, self-doubt, or increased distress.

Cognitive Effects Associated With Grief

Cognitive Effects Associated With Grief

  • Confusion
  • Difficulty concentrating
  • Difficulty initiating or completing tasks
  • Forgetfulness
  • General sense of disorientation
  • Mental fatigue
  • Reduced working memory
  • Trouble making decisions
Person appearing stressed while reviewing documents

While unsettling, these cognitive changes are generally understood as a common and expected responses to loss. 

Clinical Insight: Differential Considerations

Cognitive changes associated with grief can resemble features of depression, neurocognitive disorders, or trauma-related conditions. When these changes are inaccurately interpreted, it may contribute to inappropriate intervention or missed opportunities for grief-informed support.

What Imaging Reveals

Research suggests that grief is associated with changes in brain activity, particularly in regions involved in emotion and memory. Neuroimaging studies suggest that grief is associated with changes in brain activity and cognitive processes, including altered activation in regions involved in emotional processing, memory, and attachment. These changes are understood as part of the brain’s response to loss. 

Grief and Medical Decision-Making

Emotional and psychological distress in serious illness has been associated with difficulty understanding and recalling medical information, which can affect communication and participation in shared decision-making. These changes may be important for healthcare professionals to recognize when supporting patients and supporters.

Healthcare worker speaks with patient in hospital room

Practices such as using the teach-back method to check understanding and including family members or other supporters in communication, particularly in serious illness or end-of-life contexts, can help build shared understanding and align care with the person’s values and experience. 

These approaches reflect well-established principles of patient-centered care. In the context of grief, applying these principles can be especially important. 

Grief-Sensitive Care

Understanding these changes can help normalize the grief experience for individuals and their supporters. When healthcare professionals recognize and explain them as part of the brain’s adaptive response to loss, it can support empathy, reassurance, and more attuned care.